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this phenomenon is also the mechanism of fibrotic reaction in most organs (3)

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In addition, we have performed proof-of-principle experiments that such experimental models will prove useful in the discovery and validation of molecularly targeted therapies

3.4.3 Incentive mechanisms for the adaptation of FBS alternatives The reduction and replacement of FBS use with alternatives are becoming feasible as hPL and other serum-free substitutes have demonstrated performance comparable to that of FBS, supporting MSCs proliferation without compromising phenotypic stability, and enhancing monoclonal antibodies production in hybridoma cell lines (Even et al., 2006